Hydrochloric Acid → 2-methoxy-5-(5-trifluoromethyl-1H-tetrazol-1-yl)benzoic acid

HRID 429497Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 429497
[CH3:1][O:2][C:3]1[CH:12]=[CH:11][C:10]([N:13]2[C:17]([C:18]([F:21])([F:20])[F:19])=[N:16][N:15]=[N:14]2)=[CH:9][C:4]=1[C:5]([O:7]C)=[O:6].[OH-].[Na+].Cl>CO.O1CCCC1>[CH3:1][O:2][C:3]1[CH:12]=[CH:11][C:10]([N:13]2[C:17]([C:18]([F:21])([F:19])[F:20])=[N:16][N:15]=[N:14]2)=[CH:9][C:4]=1[C:5]([OH:7])=[O:6]

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 18464579methyl 2-methoxy-5-(5-trifluoromethyl-1H-tetrazol-1-yl)benzoate

Produkt 1

HCID 184646042-methoxy-5-(5-trifluoromethyl-1H-tetrazol-1-yl)benzoic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 21899815MeOH tetrahydrofuranLösungsmittel

Versuchsvorschrift

Combine methyl 2-methoxy-5-(5-trifluoromethyl-1H-tetrazol-1-yl)benzoate (1.46 g, 5.27 mmol) and an aqueous solution of sodium hydroxide (20 mL, 2 M, 40 mmol) in methanol/tetrahydrofuran (20 mL/10 mL). After 2 hours, adjust the pH of the reaction mixture to about 2 using a 1M aqueous hydrochloric acid solution. Extract the reaction mixture with ethyl acetate and then dichloromethane. Dry the combined organic layers over MgSO4, filter, and evaporate in vacuo to give a the title compound: Rf=0.55 (silica gel, 85% chloroform/10% methanol/5% acetic acid).

Aufarbeitung

  1. extractionExtract the reaction mixture with ethyl acetate
  2. dry with materialDry the combined organic layers over MgSO4
  3. filtrationfilter
  4. customevaporate in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-40d66dd14ab343a5a3d15d3d76bb9d42
Quelldatensatz
uspto-grants-2001_11
Patentnummer
US06316445B1

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