N,N-Dimethylethylenediamine → 2-[2-(dimethylamino)ethylamino]-4-nitro-1H-benzimidazole

HRID 429653Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 429653
Cl[C:2]1[NH:6][C:5]2[CH:7]=[CH:8][CH:9]=[C:10]([N+:11]([O-:13])=[O:12])[C:4]=2[N:3]=1.[CH3:14][N:15]([CH3:19])[CH2:16][CH2:17][NH2:18].C(=O)(O)[O-].[Na+]>>[CH3:14][N:15]([CH3:19])[CH2:16][CH2:17][NH:18][C:2]1[NH:6][C:5]2[CH:7]=[CH:8][CH:9]=[C:10]([N+:11]([O-:13])=[O:12])[C:4]=2[N:3]=1

Komponenten

4

Edukt 3

HCID 66053N,N-DimethylethylenediamineHCID 516892Sodium BicarbonateHCID 14765451HCID 14765451, Verbindung

Produkt 1

HCID 183786772-[2-(dimethylamino)ethylamino]-4-nitro-1H-benzimidazole

Reaktionsbedingungen

Temperatur
80 °C

Versuchsvorschrift

A mixture of 2-chloro-4-nitro-1H-benzimidazole (300 mg) and N,N-dimethylethylenediamine (2 ml) were stirred at 80° C. for 8 hours. The reaction mixture was poured into saturated sodium bicarbonate aqueous solution and extracted with a mixture of chloroform and methanol. The organic layer was washed with brine, dried over magnesium sulfate and evaporated in vacuo. The resiude was washed with diisopropyl ether to give 2-[[2-(dimethylamino)ethyl]amino]-4-nitro-1H-benzimidazole (113 mg).

Aufarbeitung

  1. extractionextracted with a mixture of chloroform and methanol
  2. washThe organic layer was washed with brine
  3. dry with materialdried over magnesium sulfate
  4. customevaporated in vacuo
  5. washThe resiude was washed with diisopropyl ether

Quellen und Nachweise

ORD-Eintrag
ord-717ff083e89c4fddb7799ab63eab60f0
Quelldatensatz
uspto-grants-2001_11
Patentnummer
US06316482B1

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