tert-Butyl methyl ether → HCID 178435105, Verbindung

HRID 429786

Reaktionsgleichung

Reaktionsgleichung von HRID 429786
[CH3:1][C:2]1[N:3]=[CH:4][S:5][C:6]=1[CH3:7].[Br:8]CC([C:12]1[S:13][CH:14]=[CH:15][CH:16]=1)=O.C[O:18][C:19](C)(C)[CH3:20]>C(O)C>[Br-:8].[SH:13]1([C:19](=[O:18])[CH2:20][N+:3]2[C:2]([CH3:1])=[C:6]([CH3:7])[S:5][CH:4]=2)[CH:12]=[CH:16][CH:15]=[CH:14]1

Komponenten

5

Edukt 3

HCID 15413tert-Butyl methyl etherHCID 625104,5-DimethylthiazoleHCID 27763722-Bromo-1-(thiophen-2-yl)ethan-1-one

Produkt 1

HCID 178435105HCID 178435105, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

A solution of 4,5-dimethylthiazole (2,2 g, 19.4 mmol) and 2-bromoacetylthiophene (4 g, 19.4 mmol) in ethyl alcohol (20 mL) was refluxed for 3 hours. It was cooled to room temperature and t-butyl methyl ether (10 mL) was added. The reaction mixture was left at room temperature overnight with stirring. The white product separated and was filtered and dried. It was crystallized from ethyl alcohol (4.42 g, 73%), m.p. 203-205° C.

Aufarbeitung

  1. customThe white product separated
  2. filtrationwas filtered
  3. customdried
  4. customIt was crystallized from ethyl alcohol (4.42 g, 73%), m.p. 203-205° C.

Quellen und Nachweise

ORD-Eintrag
ord-07544ed515c34ce68a593ce274f675ff
Quelldatensatz
uspto-grants-2001_11
Patentnummer
US06319934B1

Verknüpfte Notizen

Wird geladen…