HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
HRID 430654Erstellt: 24. Oktober 2026
Butyrohydrazide → 9-Bromo-6-(4-nitrophenyl)-8-methoxy-3-propyl-11h-[1,2,4]triazolo[4,3-c][2,3]benzodiazepine
https://huagongshe.com/de/reaction/430654
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|
| Edukt | Butyrohydrazide | HCID 77079 | — |
| Edukt | 7-Bromo-8-methoxy-4-methylthio-1-(4-nitrophenyl)-5h-2,3-benzodiazepine | HCID 18183198 | — |
| Katalysator | Hydrochloric Acid | HCID 313 | — |
| Lösungsmittel | Dimethylformamide | HCID 6228 | — |
| Produkt | 9-Bromo-6-(4-nitrophenyl)-8-methoxy-3-propyl-11h-[1,2,4]triazolo[4,3-c][2,3]benzodiazepine | HCID 18183189 | 83% |
Reaktionsschritte
1.17 g (2.78 mmol) of the compound of step B is dissolved in 40 ml of anhydrous DMF and mixed with 0.73 g (8.4 mmol) of butyric acid hydrazide as well as 3 drops of concentrated HCl. The mixture is stirred for 5 hours at 110-115° C. Then, the mixture is poured onto ice (160 g) and stirred for 1 more hour. The precipitated crystals are suctioned off and washed with water. 1.05 g (83%) of 9-bromo-6-(4-nitrophenyl)-8-methoxy-3-propyl-11H-[1,2,4]triazolo(4,3-c][2,3]benzodiazepine with a melting point of 238-240° C. is obtained.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patentnummer | US06323197B1 |
|---|
| Quelldatensatz | uspto-grants-2001_11 |
|---|
| ORD ID | ord-728f87f35c844e35992bb1586774ce43 |
|---|
| Quellennotiz | uspto-grants-2001_11 |
|---|
