Ethanol → Ethyl [1-(3,4-dichlorobenzyl)piperidin-4-yl]acetate

HRID 430696Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 430696
[CH2:1]([O:3][C:4](=[O:21])[CH:5]=[C:6]1[CH2:11][CH2:10][N:9]([CH2:12][C:13]2[CH:18]=[CH:17][C:16]([Cl:19])=[C:15]([Cl:20])[CH:14]=2)[CH2:8][CH2:7]1)[CH3:2].C(O)C>O1CCCC1.[Pt]=O>[Cl:20][C:15]1[CH:14]=[C:13]([CH:18]=[CH:17][C:16]=1[Cl:19])[CH2:12][N:9]1[CH2:8][CH2:7][CH:6]([CH2:5][C:4]([O:3][CH2:1][CH3:2])=[O:21])[CH2:11][CH2:10]1

Komponenten

5

Edukt 2

HCID 702EthanolHCID 18351421HCID 18351421, Verbindung

Produkt 1

HCID 10758769Ethyl [1-(3,4-dichlorobenzyl)piperidin-4-yl]acetateAusbeute 99,5 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 82844Platinum oxide (PtO)KatalysatorHCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

Ethyl[1-(3,4-dichlorobenzyl)piperidin-4-ylidene]acetate (3.9 g, 11.9 mmol) dissolved in tetrahydrofuran (25 ml) and ethanol (25 ml) was subjected to hydrogenation over platinum oxide (0.1 g) at ambient temperature and atmospheric pressure. The reaction mixture was filtered through a celite pad and concentrated in vacuo to give ethyl [1-(3,4-dichlorobenzyl)piperidin-4-yl]acetate (3.91 g) as a semi-solid.

Aufarbeitung

  1. filtrationThe reaction mixture was filtered through a celite pad
  2. concentrationconcentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-5e889fefb43d4f9d9ebaf96dc09d9961
Quelldatensatz
uspto-grants-2001_11
Patentnummer
US06323223B1

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