Methanol → N-Benzylacetamide

HRID 430703

Reaktionsgleichung

Reaktionsgleichung von HRID 430703
[CH2:1]([NH2:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(N(CC)CC)C.[C:16](Cl)(=[O:18])[CH3:17].CO>C(Cl)Cl>[C:16]([NH:8][CH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1)(=[O:18])[CH3:17]

Komponenten

6

Edukt 4

HCID 887MethanolHCID 6367Acetyl chlorideHCID 7504BenzylamineHCID 8471Triethylamine

Produkt 1

HCID 11500N-BenzylacetamideAusbeute 61 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

10 g of benzylamine was dissolved in 200 ml of methylene chloride followed by the addition of 26 ml of triethylamine and dropwise addition of 7.3 ml of acetyl chloride at 0° C. After stirring for 1 hour at room temperature, 2 ml of methanol was added to the reaction system at 0° C. followed by 120 ml of water and separation of the phases. The aqueous layer was extracted with 100 ml of chloroform, and the resulting organic layer was concentrated after drying with anhydrous sodium sulfate to obtain 8.55 g of the target compound (yield: 61%).

Aufarbeitung

  1. customfollowed by 120 ml of water and separation of the phases
  2. extractionThe aqueous layer was extracted with 100 ml of chloroform
  3. concentrationthe resulting organic layer was concentrated
  4. dry with materialafter drying with anhydrous sodium sulfate

Quellen und Nachweise

ORD-Eintrag
ord-9f8371a37d84470292733eecc32aa446
Quelldatensatz
uspto-grants-2001_11
Patentnummer
US06323212B1

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