HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Methanol → HCID 178480841, Verbindung
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Methanol | HCID 887 | — |
| Edukt | MeOH tetrahydrofuran | HCID 21899815 | — |
| Edukt | 8-Naphthalen-1-yl-quinoxaline-5-carboxylic acid [4-(4-methyl-piperazin-1-yl)phenyl]-amide | HCID 44515355 | — |
| Edukt | HCID 178480844 | HCID 178480844 | — |
| Katalysator | Nickel | HCID 935 | — |
| Lösungsmittel | Dichloromethane methanol | HCID 21226129 | — |
| Produkt | HCID 178480841 | HCID 178480841 | — |
Reaktionsschritte
The title compound was prepared in analogy to the procedures described in Example 14 but using 8-naphthalen-1-yl-quinoxaline-5-carboxylic acid (Example 46) in Step 14.1, Raney nickel and MeOH/THF (1:1) instead of palladium on carbon and MeOH in Step 14.2 and 1-methyl-4-(2-nitro-1H-imidazol-4-ylmethyl)-piperazine (Step 20.1) instead of 2-nitroimidazole in Step 14.3. Title compound: ESI-MS: 478.1 [M+H]+; tR=3.36 min (System 1); TLC: Rf=0.15 (DCM/MeOH, 9:1).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08536175B2 |
| Quelldatensatz | uspto-grants-2013_09 |
| ORD ID | ord-2ca717b309df491c833649020f262490 |
| Quellennotiz | uspto-grants-2013_09 |