Isoquinoline-4-boronic acid → 8-Isoquinolin-4-yl-quinoxaline-5-carboxylic acid [3-(4-ethyl-piperazin-1-yl)phenyl]-amide

HRID 43082

Reaktionsgleichung

Reaktionsgleichung von HRID 43082
[CH2:1]([N:3]1[CH2:8][CH2:7][N:6]([C:9]2[CH:10]=[C:11]([CH:13]=[CH:14][CH:15]=2)[NH2:12])[CH2:5][CH2:4]1)[CH3:2].[CH:16]1[C:25]2[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=2)[C:19]([C:26]2[C:35]3[N:34]=[CH:33][CH:32]=[N:31][C:30]=3[C:29]([C:36](O)=[O:37])=[CH:28][CH:27]=2)=[CH:18][N:17]=1.C1C2C(=CC=CC=2)C(B(O)O)=CN=1>>[CH2:1]([N:3]1[CH2:4][CH2:5][N:6]([C:9]2[CH:10]=[C:11]([NH:12][C:36]([C:29]3[C:30]4[N:31]=[CH:32][CH:33]=[N:34][C:35]=4[C:26]([C:19]4[C:20]5[C:25](=[CH:24][CH:23]=[CH:22][CH:21]=5)[CH:16]=[N:17][CH:18]=4)=[CH:27][CH:28]=3)=[O:37])[CH:13]=[CH:14][CH:15]=2)[CH2:7][CH2:8]1)[CH3:2]

Komponenten

4

Edukt 3

HCID 3761204Isoquinoline-4-boronic acidHCID 223301053-(4-Ethylpiperazin-1-yl)anilineHCID 669145128-Isoquinolin-4-yl-quinoxaline-5-carboxylic acid

Produkt 1

HCID 445156698-Isoquinolin-4-yl-quinoxaline-5-carboxylic acid [3-(4-ethyl-piperazin-1-yl)phenyl]-amide

Versuchsvorschrift

The title compound was prepared in analogy to the procedure described in Step 14.1 but using 3-(4-ethylpiperazin-1-yl)-aniline (Step 2.1) and 8-isoquinolin-4-yl-quinoxaline-5-carboxylic acid. The latter compound was synthesized as described in Steps 1.2-1.7 but using 4-isoquinolineboronic acid in Step 1.4. Title compound: ESI-MS: 489.2 [M+H]+; tR=11.28 min (System 2).

Aufarbeitung

  1. customThe title compound was prepared in analogy to the procedure
  2. customThe latter compound was synthesized

Quellen und Nachweise

ORD-Eintrag
ord-52ef3b22410d44a3bc3e8ff2635df5e4
Quelldatensatz
uspto-grants-2013_09
Patentnummer
US08536175B2

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