Ethanol → Ethyl 3-hydroxy-2-(hydroxymethyl)-2-methylpropanoate

HRID 43230

Reaktionsgleichung

Reaktionsgleichung von HRID 43230
[CH2:1]([C:3]([CH2:8][OH:9])([CH3:7])[C:4]([OH:6])=[O:5])[OH:2].[CH2:10](O)[CH3:11]>>[CH2:1]([C:3]([CH2:8][OH:9])([CH3:7])[C:4]([O:6][CH2:10][CH3:11])=[O:5])[OH:2]

Komponenten

3

Edukt 2

HCID 702EthanolHCID 78501Dimethylolpropionic acid

Produkt 1

HCID 23370761Ethyl 3-hydroxy-2-(hydroxymethyl)-2-methylpropanoate

Versuchsvorschrift

2,2-bis(methylol)propionic acid (bis-MPA) (22.1 g, 0.165 mol) was added in ethanol (150 mL) with Amberlyst-15 (6.8 g) and refluxed overnight. The resins were then filtered out and the filtrate was evaporated. Methylene chloride (200 mL) was added to the resulting viscous liquid to filter the unreacted reagent and by-products. The solution was dried over Mg504, filtered, and the solvent was removed in vacuo. Ethyl 2,2-bis(methylol)propionate was obtained as a clear and colorless liquid (21.1 g, 86% yield).

Aufarbeitung

  1. temperaturerefluxed overnight
  2. filtrationThe resins were then filtered out
  3. customthe filtrate was evaporated
  4. additionMethylene chloride (200 mL) was added to the resulting viscous liquid
  5. filtrationto filter the unreacted reagent and by-products
  6. customThe solution was dried over Mg504
  7. filtrationfiltered
  8. customthe solvent was removed in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-1bf505e21da74291b496869102b38a9a
Quelldatensatz
uspto-grants-2013_09
Patentnummer
US08536291B2

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