Potassium Carbonate → 2,2-Dimethyl-3-(4-pyridin-3-yl-imidazol-1-yl)-propanol

HRID 432572Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 432572
C([O:4][CH2:5][C:6]([CH3:20])([CH3:19])[CH2:7][N:8]1[CH:12]=[C:11]([C:13]2[CH:14]=[N:15][CH:16]=[CH:17][CH:18]=2)[N:10]=[CH:9]1)(=O)C.C([O-])([O-])=O.[K+].[K+]>CO>[CH3:19][C:6]([CH3:20])([CH2:7][N:8]1[CH:12]=[C:11]([C:13]2[CH:14]=[N:15][CH:16]=[CH:17][CH:18]=2)[N:10]=[CH:9]1)[CH2:5][OH:4]

Komponenten

4

Edukt 2

HCID 11430Potassium CarbonateHCID 545188152,2-Dimethyl-3-(4-pyridin-3-yl-imidazol-1-yl)-propyl acetate

Produkt 1

HCID 187597722,2-Dimethyl-3-(4-pyridin-3-yl-imidazol-1-yl)-propanol

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel2×

Versuchsvorschrift

To a solution of 2,2-Dimethyl-3-(4-pyridin-3-yl-imidazol-1-yl)-propyl acetate (20 mg) in methanol was added saturated solution of K2CO3 in metanol (1.5 mL) and the resulting solution was stirred at room temperature for 1 hour. MeOH was evaporated in vacuo and water was added followed by CH2Cl2. The aqueous layer was extracted with CHCl3, the combined organic layers were washed with brine, dried over Na2SO4 and evaporated in vacuo to afford the title compound as a slightly yellow oil.

Aufarbeitung

  1. customMeOH was evaporated in vacuo and water
  2. additionwas added
  3. extractionThe aqueous layer was extracted with CHCl3
  4. washthe combined organic layers were washed with brine
  5. dry with materialdried over Na2SO4
  6. customevaporated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-8501f40c84da40fcb82da15640b238aa
Quelldatensatz
uspto-grants-2003_12
Patentnummer
US06664238B1

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