2,4-Difluorophenol → 3,4-Bis(4-methoxyphenyl)-6-(2,4-difluorophenoxy)pyridazine

HRID 432623Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 432623
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[N:10]=[N:11][C:12](Cl)=[CH:13][C:14]=2[C:15]2[CH:20]=[CH:19][C:18]([O:21][CH3:22])=[CH:17][CH:16]=2)=[CH:5][CH:4]=1.[F:24][C:25]1[CH:30]=[C:29]([F:31])[CH:28]=[CH:27][C:26]=1[OH:32]>>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[N:10]=[N:11][C:12]([O:32][C:26]3[CH:27]=[CH:28][C:29]([F:31])=[CH:30][C:25]=3[F:24])=[CH:13][C:14]=2[C:15]2[CH:20]=[CH:19][C:18]([O:21][CH3:22])=[CH:17][CH:16]=2)=[CH:5][CH:4]=1

Komponenten

3

Edukt 2

HCID 1230512,4-DifluorophenolHCID 125680843,4-Bis(4-methoxyphenyl)-6-chloropyridazine

Produkt 1

HCID 187599973,4-Bis(4-methoxyphenyl)-6-(2,4-difluorophenoxy)pyridazine

Versuchsvorschrift

In a similar manner as in Example 2, 3,4-bis(4-methoxyphenyl)-6-chloropyridazine (200 mg, 0.613 mmol) and 2,4-difluorophenol were reacted as starting materials at 120° C. for 13 hours and post-treatment was then conducted, whereby the title compound was obtained as a colorless crystalline powder (136 mg, 52.5%). Melting point: 141.7-142.5° C. (diethyl ether-hexane).

Aufarbeitung

  1. customat 120° C.
  2. customfor 13 hours

Quellen und Nachweise

ORD-Eintrag
ord-54a4d3ee2d474f3889569ea850215ab9
Quelldatensatz
uspto-grants-2003_12
Patentnummer
US06664256B1

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