3,4-Difluorophenol → 3,4-Bis(4-methoxyphenyl)-6-(3,4-difluorophenoxy)pyridazine

HRID 432626Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 432626
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[N:10]=[N:11][C:12](Cl)=[CH:13][C:14]=2[C:15]2[CH:20]=[CH:19][C:18]([O:21][CH3:22])=[CH:17][CH:16]=2)=[CH:5][CH:4]=1.[F:24][C:25]1[CH:26]=[C:27]([OH:32])[CH:28]=[CH:29][C:30]=1[F:31]>>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[N:10]=[N:11][C:12]([O:32][C:27]3[CH:28]=[CH:29][C:30]([F:31])=[C:25]([F:24])[CH:26]=3)=[CH:13][C:14]=2[C:15]2[CH:20]=[CH:19][C:18]([O:21][CH3:22])=[CH:17][CH:16]=2)=[CH:5][CH:4]=1

Komponenten

3

Edukt 2

HCID 759273,4-DifluorophenolHCID 125680843,4-Bis(4-methoxyphenyl)-6-chloropyridazine

Produkt 1

HCID 101590923,4-Bis(4-methoxyphenyl)-6-(3,4-difluorophenoxy)pyridazine

Versuchsvorschrift

In a similar manner as in Example 2, 3,4-bis(4-methoxyphenyl)-6-chloropyridazine (150 mg, 0.459 mmol) and 3,4-difluorophenol were reacted as starting materials at 150° C. for 14 hours and post-treatment was then conducted, whereby the title compound was obtained as a pale yellow amorphous solid (190.2 mg, 99.1%).

Aufarbeitung

  1. customat 150° C.
  2. customfor 14 hours

Quellen und Nachweise

ORD-Eintrag
ord-d1f232ecf8d54389a7e736ff7d2de038
Quelldatensatz
uspto-grants-2003_12
Patentnummer
US06664256B1

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