2-iodo-N,N-dimethylaniline → HCID 18760183, Verbindung
Reaktionsgleichung
[O:1]([C:8]1[C:17]2[N:18]=[CH:19][N:20]([CH2:21][CH2:22][O:23][CH2:24][C:25]#[CH:26])[C:16]=2[C:15]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[N:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.I[C:28]1[CH:36]=[CH:35][CH:34]=[CH:33][C:29]=1[N:30](C)[CH3:31]>>[CH3:31][N:30]1[C:29]2[C:28](=[CH:36][CH:35]=[CH:34][CH:33]=2)[CH:26]=[C:25]1[CH2:24][O:23][CH2:22][CH2:21][N:20]1[C:16]2[C:15]3[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=3[N:9]=[C:8]([O:1][C:2]3[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=3)[C:17]=2[N:18]=[CH:19]1Komponenten
3
Versuchsvorschrift
Using the general method of Example 30 Part D, 4-phenoxy-1-[2-(prop-2-ynyloxy)ethyl]-1H-imidazo[4,5-c]quinoline (3.16 g, 9.20 mmol) was reacted with 2-iodo-N,N-dimethylaniline (2.5 g, 10.1 mmol) to provide a 1.0 g of 1-{2-[(1-methyl-1H-indol-2-yl)methoxy]ethyl }-4-phenoxy-1H-imidazo[4,5-c]quinoline as a pale yellow crystalline solid.
Quellen und Nachweise
- ORD-Eintrag
- ord-c81d48d8266845c8a24a5f10f5689232
- Quelldatensatz
- uspto-grants-2003_12