Hydrochloric Acid → 1-(2-(Thiophen-2-yl)acetyl)piperidine-3-carboxylic acid

HRID 432802Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 432802
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH2:6][C:7]([N:9]1[CH2:14][CH2:13][CH2:12][CH:11]([C:15]([O:17]CC)=[O:16])[CH2:10]1)=[O:8].[OH-].[Na+].Cl>C(O)C>[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH2:6][C:7]([N:9]1[CH2:14][CH2:13][CH2:12][CH:11]([C:15]([OH:17])=[O:16])[CH2:10]1)=[O:8]

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 3273150Ethyl 1-(2-thiophen-2-ylacetyl)piperidine-3-carboxylate

Produkt 1

HCID 167909951-(2-(Thiophen-2-yl)acetyl)piperidine-3-carboxylic acidAusbeute 91,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

Ethyl 1-(2-thiopheneacetyl)-3-piperidinecarboxylate (256.4 mg; 0.91 mmol) was dissolved in absolute ethanol (5 ml). 1 N sodium hydroxide (10 ml) was added and the mixture was allowed to stir at ambient temperature for approximately 1 hour. It was then poured into 1 N HCl and extracted with dichloromethane. The dichloromethane was dried with magnesium sulfate and then evaporated at ambient temperature under reduced pressure, giving 1-(2-thiopheneacetyl)-3-piperidine carboxylic acid (210.1 mg) as a thick, yellow oil which solidified without further purification. MS m/z (positive ion) 254 (MH+; 100).

Aufarbeitung

  1. extractionextracted with dichloromethane
  2. dry with materialThe dichloromethane was dried with magnesium sulfate
  3. customevaporated at ambient temperature under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-d66a4369f1e14ebc8957d3c666a027cf
Quelldatensatz
uspto-grants-2003_12
Patentnummer
US06664271B1

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