(S)-ethyl 1-(2-thiopheneacetyl)-3-piperidinecarboxylate → (S)-1-(2-Thiopheneacetyl)-3-piperidine Carboxylic Acid

HRID 432817Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 432817
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH2:6][C:7]([N:9]1[CH2:14][CH2:13][CH2:12][CH:11]([C:15]([OH:17])=[O:16])[CH2:10]1)=[O:8].S1C=CC=C1CC(N1CCC[C@H](C(OCC)=O)C1)=O>>[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH2:6][C:7]([N:9]1[CH2:14][CH2:13][CH2:12][C@H:11]([C:15]([OH:17])=[O:16])[CH2:10]1)=[O:8]

Komponenten

3

Edukt 2

HCID 9838651(S)-ethyl 1-(2-thiopheneacetyl)-3-piperidinecarboxylateHCID 167909951-(2-(Thiophen-2-yl)acetyl)piperidine-3-carboxylic acid

Produkt 1

HCID 10198935(S)-1-(2-Thiopheneacetyl)-3-piperidine Carboxylic Acid

Versuchsvorschrift

This reaction was run in the same manner as 1-(2-thiopheneacetyl)-3-piperidine carboxylic acid, starting with (S)-ethyl 1-(2-thiopheneacetyl)-3-piperidinecarboxylate (10 g; 35.6). This gave (S)-1-(2-thiopheneacetyl)-3-piperidine carboxylic acid (9.27 g) as a white solid without further purification. MS m/z (positive ion) 506 (dimer+; 25), 254 (MH+; 100).

Aufarbeitung

  1. customThis gave (S)-1-(2-thiopheneacetyl)-3-piperidine carboxylic acid (9.27 g) as a white solid without further purification

Quellen und Nachweise

ORD-Eintrag
ord-c707a4c9e1e94e03939d667a1d9844e8
Quelldatensatz
uspto-grants-2003_12
Patentnummer
US06664271B1

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