2-Methyl-1H-indole-3-ethylamine → Phenylhydrazine

HRID 43285

Reaktionsgleichung

Reaktionsgleichung von HRID 43285
[ClH:1].CO[C:4](=[O:27])/[CH:5]=[CH:6]/[C:7]1C=CC(CNCCC2[C:25]3[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=3)[NH:19]C=2C)=CC=1.[CH3:28]C1NC2C(=CC=CC=2)C=1CC[NH2:33]>C(O)C>[C:20]1([NH:19][NH2:33])[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1.[Cl:1][CH2:7][CH2:6][CH2:5][C:4](=[O:27])[CH3:28]

Komponenten

5

Edukt 2

HCID 759492-Methyl-1H-indole-3-ethylamineHCID 23652684Panobinostat Carboxylic Acid Methyl Ester Hydrochloride

Produkt 2

HCID 7516PhenylhydrazineHCID 799932-Pentanone, 5-chloro-

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

The third embodiment of the present invention is directed to a method of making a starting material useful in the synthesis of (E)-3-(4-{[2-(2-methyl-1H-indol-3-yl)-ethylamino]-methyl]-phenyl)-acrylic acid methyl ester hydrochloride salt. In particular, the third embodiment of the present invention is directed to a method of making 2-methyltryptamine comprising the steps of: (a) providing an admixture of phenylhydrazine and 5-chloro-2-pentanone in ethanol at a first temperature; (b) adding ethanol to the admixture and refluxing the mixture; (c) distilling ethanol; (d) adding water to the residual solution; (e) cooling the residual solution to form 2-methyltryptamine.

Quellen und Nachweise

ORD-Eintrag
ord-e45d2870354b41a69e22a30e69c1897b
Quelldatensatz
uspto-grants-2013_09
Patentnummer
US08536346B2

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