Dimethylamine → Octanamide

HRID 43303

Reaktionsgleichung

Reaktionsgleichung von HRID 43303
C[NH:2]C.[C:4](Cl)(=[O:12])[CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH3:11]>>[C:4]([NH2:2])(=[O:12])[CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH3:11]

Komponenten

3

Edukt 2

HCID 674DimethylamineHCID 8124Octanoyl chloride

Produkt 1

HCID 69414Octanamide

Reaktionsbedingungen

Temperatur
10 °C

Versuchsvorschrift

135.03 g of Dimethyl Amine solution is charged at room temperature and cooled to 10±2° C., then Octanoyl Chloride obtained in EXAMPLE 4 is charged at 8 to 12° C. over a period of 2 hours, and the reaction mixture is stirred at 10 to 15° C. for 30 minutes and then stirred at room temperature for 1 hour and the upper organic layer is separated from lower aqueous layer and 29.80 g of Sodium Chloride (20% solution) is added to the organic layer. This organic layer is washed and 9.94 g of Sodium Sulphate is added to the organic layer to take up water, and the mixture is filtered to obtain crude Octanamide.

Aufarbeitung

  1. stirringstirred at room temperature for 1 hour
  2. customthe upper organic layer is separated from lower aqueous layer and 29.80 g of Sodium Chloride (20% solution)
  3. additionis added to the organic layer
  4. washThis organic layer is washed
  5. addition9.94 g of Sodium Sulphate is added to the organic layer
  6. filtrationthe mixture is filtered

Quellen und Nachweise

ORD-Eintrag
ord-4a453be5931640edaf4b3ab0c2ecdb2b
Quelldatensatz
uspto-grants-2013_09
Patentnummer
US08536355B2

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