Formaldehyde → L-Pantothenic acid

HRID 433053

Reaktionsgleichung

Reaktionsgleichung von HRID 433053
[C:1]([OH:15])(=[O:14])[CH2:2][CH2:3][NH:4][C:5](=[O:13])[C@@H:6]([C:8]([CH2:11][OH:12])([CH3:10])[CH3:9])[OH:7].CC1(C)C(O)C(=O)OC1.C=O.[C-]#N>>[C:1]([OH:15])(=[O:14])[CH2:2][CH2:3][NH:4][C:5](=[O:13])[C@H:6]([C:8]([CH2:11][OH:12])([CH3:10])[CH3:9])[OH:7]

Komponenten

5

Edukt 4

HCID 712FormaldehydeHCID 989(+-)-PantolactoneHCID 5975CyanideHCID 6613Pantothenic Acid

Produkt 1

HCID 5748353L-Pantothenic acid

Versuchsvorschrift

Pantothenic acid can be prepared by chemical synthesis, or biotechnologically by fermentation of suitable microorganisms in suitable nutrient solutions. In chemical synthetic applications DL-pantolactone is an important intermediate stage. It is prepared in a multi-stage process from formaldehyde, isobutylaldehyde and cyanide. In further process steps, the racemic mixture is separated, D-pantolactone is subjected to a condensation reaction with β-alanine which yields the desired D-pantothenic acid.

Aufarbeitung

  1. customIn further process steps, the racemic mixture is separated
  2. customD-pantolactone is subjected to a condensation reaction with β-alanine which

Quellen und Nachweise

ORD-Eintrag
ord-eaeb4f24c93445df92028980e16463c7
Quelldatensatz
uspto-grants-2003_12
Patentnummer
US06667166B2

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