tert-Butyl 4-oxopiperidine-1-carboxylate → 1,1-Dimethylethyl 4-{[4-fluoro-3-(methyloxy)phenyl]amino}-1-piperidinecarboxylate

HRID 43345

Reaktionsgleichung

Reaktionsgleichung von HRID 43345
O=[C:2]1[CH2:7][CH2:6][N:5]([C:8]([O:10][C:11]([CH3:14])([CH3:13])[CH3:12])=[O:9])[CH2:4][CH2:3]1.[F:15][C:16]1[CH:22]=[CH:21][C:19]([NH2:20])=[CH:18][C:17]=1[O:23][CH3:24].FC1C=CC(NC2CCN(C(OC(C)(C)C)=O)CC2)=CC=1>>[F:15][C:16]1[CH:22]=[CH:21][C:19]([NH:20][CH:2]2[CH2:7][CH2:6][N:5]([C:8]([O:10][C:11]([CH3:14])([CH3:13])[CH3:12])=[O:9])[CH2:4][CH2:3]2)=[CH:18][C:17]=1[O:23][CH3:24]

Komponenten

4

Edukt 3

HCID 735900tert-Butyl 4-oxopiperidine-1-carboxylateHCID 27745334-Fluoro-3-methoxyanilineHCID 16413902tert-Butyl 4-(4-fluoroanilino)piperidine-1-carboxylate

Produkt 1

HCID 576995241,1-Dimethylethyl 4-{[4-fluoro-3-(methyloxy)phenyl]amino}-1-piperidinecarboxylate

Versuchsvorschrift

The title compound was prepared from 1,1-dimethylethyl 4-oxo-1-piperidinecarboxylate and 4-fluoro-3-methoxyaniline using a method similar to that described for D1.

Quellen und Nachweise

ORD-Eintrag
ord-2bf0537e4add40a7bc33873b1154f9a7
Quelldatensatz
uspto-grants-2013_09
Patentnummer
US08536182B2

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