Triethylamine → 1,1-Dimethylethyl (2S)-4-({2-chloro-4-[2-(methyloxy)-2-oxoethyl]phenyl}methyl)-2-methyl-1-piperazinecarboxylate

HRID 43357

Reaktionsgleichung

Reaktionsgleichung von HRID 43357
[Cl:1][C:2]1[CH:3]=[C:4]([CH2:10][C:11]([O:13][CH3:14])=[O:12])[CH:5]=[CH:6][C:7]=1[CH:8]=O.Cl.[CH3:16][C@H:17]1[CH2:22][NH:21][CH2:20][CH2:19][N:18]1[C:23]([O:25][C:26]([CH3:29])([CH3:28])[CH3:27])=[O:24].BrC1C=CC(CN2CCN(C(OCC3C=CC=CC=3)=O)[C@@H](C)C2)=CC=1.C(N(CC)CC)C>>[Cl:1][C:2]1[CH:3]=[C:4]([CH2:10][C:11]([O:13][CH3:14])=[O:12])[CH:5]=[CH:6][C:7]=1[CH2:8][N:21]1[CH2:20][CH2:19][N:18]([C:23]([O:25][C:26]([CH3:29])([CH3:28])[CH3:27])=[O:24])[C@@H:17]([CH3:16])[CH2:22]1

Komponenten

5

Edukt 4

HCID 8471TriethylamineHCID 25224210Phenylmethyl (2S)-4-[(4-bromophenyl)methyl]-2-methyl-1-piperazine CarboxylateHCID 45072182(S)-tert-butyl 2-methylpiperazine-1-carboxylate hydrochlorideHCID 59520437Methyl (3-chloro-4-formylphenyl)acetate

Produkt 1

HCID 671280471,1-Dimethylethyl (2S)-4-({2-chloro-4-[2-(methyloxy)-2-oxoethyl]phenyl}methyl)-2-methyl-1-piperazinecarboxylate

Versuchsvorschrift

The title compound was prepared from methyl (3-chloro-4-formylphenyl)acetate (Epple, R. et al., PCT Int. Appl. WO2005116000) and 1,1-dimethylethyl (2S)-2-methyl-1-piperazinecarboxylate hydrochloride using a method similar to that described for D6 with the addition of triethylamine (1.1 eq) to the reaction mixture and a reaction time of ˜3 days.

Aufarbeitung

  1. customa reaction time of ˜3 days

Quellen und Nachweise

ORD-Eintrag
ord-e9595488509d4501862848e21dae7740
Quelldatensatz
uspto-grants-2013_09
Patentnummer
US08536182B2

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