HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
3-Fluoroaniline → tert-Butyl 4-(3-fluoroanilino)piperidine-1-carboxylate
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 3-Fluoroaniline | HCID 9742 | — |
| Edukt | tert-Butyl 4-oxopiperidine-1-carboxylate | HCID 735900 | — |
| Edukt | Sodium triacetoxyborohydride | HCID 5049666 | — |
| Lösungsmittel | Isopropyl Acetate | HCID 7915 | — |
| Produkt | tert-Butyl 4-(3-fluoroanilino)piperidine-1-carboxylate | HCID 23137591 | — |
Reaktionsschritte
Sodium triacetoxyborohydride (NaBH(OAc)3 74 g, 0.35 mol) was added to a stirred solution of 1,1-Dimethylethyl 4-oxo-1-piperidinecarboxylate (50 g, 0.25 mol) and 3-Fluoroaniline (24 ml, 0.25 mol) in isopropyl acetate (1-PrOAc, 500 ml) and the slurry stirred overnight.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08536182B2 |
| Quelldatensatz | uspto-grants-2013_09 |
| ORD ID | ord-37cc2d7a1d7c499ab3bcccd0f2ba04eb |
| Quellennotiz | uspto-grants-2013_09 |