Boron, trifluoro(methanol)-, (T-4)- → HCID 86584267, Verbindung

HRID 433727

Reaktionsgleichung

Reaktionsgleichung von HRID 433727
CO.B(F)(F)F.C([NH:10][C:11]1[C:12]([F:32])=[CH:13][C:14]([Cl:31])=[C:15]([CH:30]=1)[O:16][C:17]1[CH:29]=[CH:28][CH:27]=[CH:26][C:18]=1[O:19][CH2:20][C:21]([O:23][CH2:24][CH3:25])=[O:22])(=O)C>>[NH2:10][C:11]1[C:12]([F:32])=[CH:13][C:14]([Cl:31])=[C:15]([CH:30]=1)[O:16][C:17]1[CH:29]=[CH:28][CH:27]=[CH:26][C:18]=1[O:19][CH2:20][C:21]([O:23][CH2:24][CH3:25])=[O:22]

Komponenten

3

Edukt 2

HCID 11062313Boron, trifluoro(methanol)-, (T-4)-HCID 86584266HCID 86584266, Verbindung

Produkt 1

HCID 86584267HCID 86584267, Verbindung

Versuchsvorschrift

Into a boron trifluoride methanol complex methanol solution is added ethyl [2-(5-acetylamino-2-chloro-4-fluorophenoxy)phenoxy]acetate, and the mixture is heated while stirring. Thereafter, the reaction solution is concentrated, the residue is dissolved in ethyl acetate, and washed with saturated aqueous sodium bicarbonate, dried over magnesium sulfate, and concentrated to obtain ethyl [2-(5-amino-2-chloro-4-fluorophenoxy)phenoxy]acetate [Intermediate compound A3-23].

Aufarbeitung

  1. temperaturethe mixture is heated
  2. concentrationThereafter, the reaction solution is concentrated
  3. dissolutionthe residue is dissolved in ethyl acetate
  4. washwashed with saturated aqueous sodium bicarbonate
  5. dry with materialdried over magnesium sulfate
  6. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-33db2df52e6946c8b20f6fd6038ad6ce
Quelldatensatz
uspto-grants-2003_12
Patentnummer
US06667413B2

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