2-Thiophenemethanol → 5-Fluoro-1-(2-thienylmethyl)pyrimidin-2-one

HRID 434653

Reaktionsgleichung

Reaktionsgleichung von HRID 434653
C(OC(OCC(C)(C)C)N(C)C)C(C)(C)C.[F:17][C:18]1[CH:19]=[N:20][C:21](=[O:24])[NH:22][CH:23]=1.O[CH2:26][C:27]1[S:28][CH:29]=[CH:30][CH:31]=1>CN(C)C=O>[F:17][C:18]1[CH:19]=[N:20][C:21](=[O:24])[N:22]([CH2:26][C:27]2[S:28][CH:29]=[CH:30][CH:31]=2)[CH:23]=1

Komponenten

5

Edukt 3

HCID 694672-ThiophenemethanolHCID 786231,1-Bis(2,2-dimethylpropoxy)-N,N-dimethylmethanamineHCID 1014985-Fluoropyrimidin-2-one

Produkt 1

HCID 204917665-Fluoro-1-(2-thienylmethyl)pyrimidin-2-one

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Reaktionsbedingungen

Temperatur
80 °C

Versuchsvorschrift

N,N-Dimethylformamide dineopentyl acetal (1.76 ml) was added to a stirred suspension of 5-fluoropyrimidin-2-one (456 mg) and 2-hydroxymethyl thiophene (0.7 ml) in dry N,N-dimethylformamide (8 ml) under nitrogen and the mixture was then heated at 80° C. After 1 h the reaction mixture was evaporated to a brown solid which was crystallised twice from ethyl acetate to give white crystals of the title pyrimidinone (230 mg), m.p. 161°-163° C., λmax (EtOH) 222.5 nm (ε 10,890), 333.5 nm (ε 3,660).

Aufarbeitung

  1. customAfter 1 h the reaction mixture was evaporated to a brown solid which
  2. customwas crystallised twice from ethyl acetate

Quellen und Nachweise

ORD-Eintrag
ord-5bc85e7cc35d42269052212a80fa49d0
Quelldatensatz
uspto-grants-1983_08
Patentnummer
US04399140

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