Sulfuric Acid → 5-Methyl-4-(trifluoromethyl)-1H-imidazole-2-carbaldehyde

Reaktionsgleichung

C[O:2][CH:3](OC)[C:4]1[NH:5][C:6]([CH3:13])=[C:7]([C:9]([F:12])([F:11])[F:10])[N:8]=1.S(=O)(=O)(O)O>>[CH3:13][C:6]1[NH:5][C:4]([CH:3]=[O:2])=[N:8][C:7]=1[C:9]([F:12])([F:10])[F:11]

Komponenten

Edukt 2

HCID 1118Sulfuric Acid

HCID 675492182-(dimethoxymethyl)-5-methyl-4-(trifluoromethyl)-1H-imidazole

Produkt 1

HCID 866484815-Methyl-4-(trifluoromethyl)-1H-imidazole-2-carbaldehydeAusbeute 7,9 %

Versuchsvorschrift

The same operation as in Example (33b) was performed using 2-(dimethoxymethyl)-5-methyl-4-(trifluoromethyl)-1H-imidazole obtained in Example (36b) (about 2.17 mmol) and 2 N sulfuric acid (15 mL), to obtain 30.5 mg of the title compound as a white solid (7.9%).

Quellen und Nachweise

ORD-Eintrag: ord-498d4b21d8644dc78b259e89ae49cdf6
Quelldatensatz: uspto-grants-2013_09
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US08536197B2

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