Ammonia → 2-(dimethoxymethyl)-5-ethyl-4-(trifluoromethyl)-1H-imidazole

HRID 43473

Reaktionsgleichung

Reaktionsgleichung von HRID 43473
[CH2:1]1[C:6](=O)[N:5](Cl)[C:3](=O)[CH2:2]1.[F:9][C:10]([F:22])([F:21])C(C1(CC)SCCCS1)=O.[CH3:23][O:24][CH:25]([O:28][CH3:29])[CH:26]=O.[NH3:30]>[N+]([O-])([O-])=O.[Ag+]>[CH3:23][O:24][CH:25]([O:28][CH3:29])[C:26]1[NH:30][C:2]([CH2:1][CH3:6])=[C:3]([C:10]([F:22])([F:21])[F:9])[N:5]=1

Komponenten

6

Edukt 4

HCID 222AmmoniaHCID 31398ChlorosuccinimideHCID 162650Acetaldehyde, 2,2-dimethoxy-HCID 866484862,2,2-Trifluoro-1-(2-ethyl-1,3-dithian-2-yl)ethanone

Produkt 1

HCID 684060432-(dimethoxymethyl)-5-ethyl-4-(trifluoromethyl)-1H-imidazole

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 24470Silver NitrateKatalysator

Versuchsvorschrift

The same operation as in Example (36b) was performed using NCS (1.35 g, 10.1 mmol), silver nitrate (2.45 g, 14.4 mmol), 2,2,2-trifluoro-1-(2-ethyl-1,3-dithian-2-yl)ethanone obtained in Example (39b) (1.0 g, 4.09 mmol), dimethoxyacetaldehyde (5.76 M aqueous solution, 1.0 mL, 5.76 mmol) and 28% aqueous ammonia (4 mL). The resulting compound was used for the next reaction without purification.

Aufarbeitung

  1. customThe resulting compound was used for the next reaction without purification

Quellen und Nachweise

ORD-Eintrag
ord-ef9ba275c62b456e8ce8698492098cc5
Quelldatensatz
uspto-grants-2013_09
Patentnummer
US08536197B2

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