Isopropyl chloroacetate → Diisopropyl malonate

HRID 434791

Reaktionsgleichung

Reaktionsgleichung von HRID 434791
[CH:1]([O:4][C:5](=[O:8])[CH2:6]Cl)([CH3:3])[CH3:2].[OH-:9].[Na+]>C(O)(C)C>[CH:1]([O:4][C:5](=[O:8])[CH2:6][C:5]([O:4][CH:1]([CH3:3])[CH3:2])=[O:9])([CH3:3])[CH3:2]

Komponenten

4

Edukt 2

HCID 7759Isopropyl chloroacetateHCID 14798Sodium Hydroxide

Produkt 1

HCID 83223Diisopropyl malonateAusbeute 92 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3776IsopropanolLösungsmittel2×

Versuchsvorschrift

20 g of Co2 (CO)8 in 2.5 liters of isopropanol and 546 g (4 moles) of chloroacetic acid isopropyl ester are placed in a pressure vessel of a capacity of 18 liters, as in Example 1. At 55° C., and a pressure of 5 bars of CO, a 2.93% solution of sodium hydroxide in isopropanol is pumped into the vessel over a period of 3 hours, maintaining a pH of 7.0. At a transformation of 82%, 615 g of malonic acid diisopropyl ester (92% yield) is obtained after the usual processing. 98 g of chloroacetic acid isopropyl ester is recovered.

Aufarbeitung

  1. temperaturemaintaining a pH of 7.0

Quellen und Nachweise

ORD-Eintrag
ord-6ef41d616fd74555927a6e5c401d3ff3
Quelldatensatz
uspto-grants-1983_08
Patentnummer
US04399300

Verknüpfte Notizen

Wird geladen…