(4-Amino-3-nitrophenyl)methanol → (3,4-Diaminophenyl)methanol

HRID 435482

Reaktionsgleichung

Reaktionsgleichung von HRID 435482
[NH2:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6][OH:7])=[CH:4][C:3]=1[N+:10]([O-])=O.[H][H]>[Ni].O1CCCC1>[NH2:10][C:3]1[CH:4]=[C:5]([CH:8]=[CH:9][C:2]=1[NH2:1])[CH2:6][OH:7]

Komponenten

5

Edukt 2

HCID 12902831(4-Amino-3-nitrophenyl)methanolHCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 12902832(3,4-Diaminophenyl)methanolAusbeute 82 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 935NickelKatalysatorHCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

Six grams (0.035 mole) of 4-amino-3-nitrobenzyl alcohol, 95 ml. of tetrahydrofuran and 0.5 g. of Raney Nickel were hydrogenated at 40 psi at room temperature until 3 moles of hydrogen were absorbed. The catalyst was filtered and the filtrate was evaporated in vacuo to yield 4.83 g. (82 percent yield) of 3,4-diaminobenzyl alcohol, mp. 74°-75° C.

Aufarbeitung

  1. customwere absorbed
  2. filtrationThe catalyst was filtered
  3. customthe filtrate was evaporated in vacuo
  4. customto yield 4.83 g

Quellen und Nachweise

ORD-Eintrag
ord-5d50edf175694989bf6919c1e830a6a9
Quelldatensatz
uspto-grants-1983_08
Patentnummer
US04401817

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