Hydrochloric Acid → 10-Chloro-10,11-dihydro-2-dimethylsulphamoyl-dibenzo[b,f]thiepin

HRID 435649Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 435649
[ClH:1].[CH3:2][N:3]([CH3:23])[S:4]([C:7]1[CH:22]=[CH:21][C:10]2[S:11][C:12]3[CH:20]=[CH:19][CH:18]=[CH:17][C:13]=3[CH:14](O)[CH2:15][C:9]=2[CH:8]=1)(=[O:6])=[O:5].[Cl-].[Ca+2].[Cl-]>C1C=CC=CC=1>[Cl:1][CH:14]1[C:13]2[CH:17]=[CH:18][CH:19]=[CH:20][C:12]=2[S:11][C:10]2[CH:21]=[CH:22][C:7]([S:4](=[O:6])(=[O:5])[N:3]([CH3:23])[CH3:2])=[CH:8][C:9]=2[CH2:15]1

Komponenten

5

Edukt 3

HCID 313Hydrochloric Acid2×HCID 5284359Calcium ChlorideHCID 12223972HCID 12223972, Verbindung

Produkt 1

HCID 1561900510-Chloro-10,11-dihydro-2-dimethylsulphamoyl-dibenzo[b,f]thiepin

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 241BenzeneLösungsmittel

Versuchsvorschrift

Hydrochloric acid gas is introduced at 10° C for 2 hours into a mixture of 12 g of 10,11-dihydro-2-dimethylsulphamoyl-dibenzo[b,f]thiepin-10-ol, 250 ml of benzene and 20 g of calcium chloride. The mixture is then left to stand at room temperature for 20 hours. The excess hydrochloric acid is driven off by the introduction of nitrogen. The mixture is filtered and evaporated under reduced pressure. 10-chloro-10,11-dihydro-2-dimethylsulphamoyl-dibenzo[b,f]thiepin is obtained.

Aufarbeitung

  1. waitThe mixture is then left
  2. filtrationThe mixture is filtered
  3. customevaporated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-cca5d19679774d61aaa2a9be6f55b303
Quelldatensatz
uspto-grants-1977_02
Patentnummer
US04006145

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