Hydrochloric Acid → 4-nitro-2-methoxy-N-(beta-aminoethyl)aniline

HRID 436336Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 436336
Cl[C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][C:3]=1[O:11][CH3:12].O.[CH2:14]([NH2:17])[CH2:15][NH2:16].C(N)CN.Cl>>[N+:8]([C:5]1[CH:6]=[CH:7][C:2]([NH:16][CH2:15][CH2:14][NH2:17])=[C:3]([O:11][CH3:12])[CH:4]=1)([O-:10])=[O:9]

Komponenten

5

Edukt 4

HCID 313Hydrochloric AcidHCID 3301EthylenediamineHCID 705192-Chloro-5-nitroanisoleHCID 12200817Ethylenediamine monohydrate

Produkt 1

HCID 214541994-nitro-2-methoxy-N-(beta-aminoethyl)anilineAusbeute 86,1 %

Versuchsvorschrift

31 g (0.165 mole) of 2-chloro-5-nitro-anisole is added to 130 cm3 (1.65 mole) ethylenediamine hydrate. The reaction mixture is heated at reflux for five hours, and the excess of ethylenediamine driven off under vacuum. The residue is treated with 200 cm3 of a 5N hydrochloric acid solution, and dried, yielding 30 g of 4-nitro-2-methoxy-N(β-aminoethyl) aniline, which is washed with acetone.

Aufarbeitung

  1. temperatureThe reaction mixture is heated
  2. temperatureat reflux for five hours
  3. customdried

Quellen und Nachweise

ORD-Eintrag
ord-9f073526c25e487a8ba76f1aeac338f3
Quelldatensatz
uspto-grants-1977_02
Patentnummer
US04008272

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