Hydrochloric Acid → 1-Hydrazinyl-3,4-dihydroisoquinoline

HRID 436430

Reaktionsgleichung

Reaktionsgleichung von HRID 436430
[NH2:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH2:5][CH2:4][N:3]=1.Cl.C(OC1C2C(=CC=CC=2)CC[N:17]=1)C.[Cl-].[NH4+].C(=O)([O-])[O-].[Na+].[Na+].NN>C(O)C>[NH:1]([C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH2:5][CH2:4][N:3]=1)[NH2:17]

Komponenten

8

Edukt 6

HCID 313Hydrochloric AcidHCID 9321HydrazineHCID 10340Sodium CarbonateHCID 25517Ammonium ChlorideHCID 97938243,4-Dihydro-isoquinolin-1-ylamineHCID 123490381-Ethoxy-3,4-dihydroisoquinoline

Produkt 1

HCID 123490411-Hydrazinyl-3,4-dihydroisoquinoline

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Reaktionsbedingungen

Temperatur
25 °C

Versuchsvorschrift

A mixture of 1-amino-3,4-dihydroisoquinoline (VI: R=R'=Y=Y'=Z=Z'=H) hydrochloride (m.p. 133°-134° C., 0.5 g.), prepared from 1-ethoxy-3,4-dihydroisoquinoline and ammonium chloride, sodium carbonate (0.38 g.), hydrazine (0.41 g.) and ethanol (15 ml.) was stirred (at 25° C.). The mixture was filtered. An ether solution of the crystals which separated from the filtrate on chilling was washed with water, dried and filtered. Concentration of the filtrate and crystallization of the residue from ether afforded 1-hydrazino-3,4-dihydroisoquinoline (0.44 g.).

Aufarbeitung

  1. filtrationThe mixture was filtered
  2. customAn ether solution of the crystals which separated from the filtrate
  3. temperatureon chilling
  4. washwas washed with water
  5. customdried
  6. filtrationfiltered
  7. customConcentration of the filtrate and crystallization of the residue from ether

Quellen und Nachweise

ORD-Eintrag
ord-c56f3b2b50184e3084ea8ec85fc05f53
Quelldatensatz
uspto-grants-1977_02
Patentnummer
US04009170

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