Acetaldehyde → 1-(2-Ethylidenehydrazino)-6,7-dimethoxy-3,4-dihydroisoquinoline
Reaktionsgleichung
[NH:1]([C:3]1[C:12]2[C:7](=[CH:8][C:9]([O:15][CH3:16])=[C:10]([O:13][CH3:14])[CH:11]=2)[CH2:6][CH2:5][N:4]=1)[NH2:2].[CH:17](=O)[CH3:18].S(=O)(=O)(O)O>>[CH:17](=[N:2][NH:1][C:3]1[C:12]2[C:7](=[CH:8][C:9]([O:15][CH3:16])=[C:10]([O:13][CH3:14])[CH:11]=2)[CH2:6][CH2:5][N:4]=1)[CH3:18]Komponenten
4
Versuchsvorschrift
In a manner similar to that of Step C of Example 1, condensation of 1-hydrazino-6,7-dimethoxy-3,4-dihydroisoquinoline (7.2 g.) with acetaldehyde (4.3 g.) and treatment of the resulting product with sulfuric acid afforded 1-(2-ethylidenehydrazino)-6,7-dimethoxy-3,4-dihydroisoquinoline (I: X=CH3, X' =Y=Y' =H, Z=Z' =CH3O) sulfate monohydrate (5.3 g., m.p. 165°-168° C.).