Acetamide, N-(2-methyl-4-nitrophenyl)- → 4'-Amino-2'-methylacetanilide

HRID 436544

Reaktionsgleichung

Reaktionsgleichung von HRID 436544
[NH:1]([C:5]1[CH:10]=[CH:9][C:8]([N+:11]([O-])=O)=[CH:7][C:6]=1[CH3:14])[C:2]([CH3:4])=[O:3].[H][H]>[Ni].CN(C)C=O>[NH:1]([C:5]1[CH:10]=[CH:9][C:8]([NH2:11])=[CH:7][C:6]=1[CH3:14])[C:2]([CH3:4])=[O:3]

Komponenten

5

Edukt 2

HCID 75936Acetamide, N-(2-methyl-4-nitrophenyl)-HCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 3143384'-Amino-2'-methylacetanilide

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 935NickelKatalysatorHCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

19.4g (0.1 mole) of 4-acetamino-3-methyl-nitrobenzene, 30g of dimethylformamide and 1g of fresh-developed Raney nickel were fed in an autoclave, 50kg/cm2 of hydrogen was then fed thereto, and, after the reaction was carried out at 60° to 120° C while stirring, the reaction mixture was removed immediately, the Raney nickel was removed while hot, and thereafter the product was poured into 100ml of methanol to separate the 4-acetamino-3-methylaniline produced.

Aufarbeitung

  1. customwas carried out at 60° to 120° C
  2. customthe reaction mixture was removed immediately
  3. customthe Raney nickel was removed while hot, and thereafter the product
  4. additionwas poured into 100ml of methanol
  5. customto separate the 4-acetamino-3-methylaniline
  6. customproduced

Quellen und Nachweise

ORD-Eintrag
ord-1170cedb5a914ef7a9703441e9dbd141
Quelldatensatz
uspto-grants-1977_02
Patentnummer
US04009205

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