HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Sulfuric Acid → 1,3-Dihydro-1,3-dioxo-2H-isoindole-2-butanal
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Sulfuric Acid | HCID 1118 | — |
| Edukt | 2-(4,4-Diethoxybutyl)isoindoline-1,3-dione | HCID 12805186 | — |
| Lösungsmittel | 4,4-Diethoxybutylamine | HCID 80672 | — |
| Produkt | 1,3-Dihydro-1,3-dioxo-2H-isoindole-2-butanal | HCID 77150 | — |
Reaktionsschritte
Protect the amino function in 4,4-diethoxybutylamine by conversion thereof to a phthalimido function. Hydrolyze the resultant 1-phthalimido-4,4-diethoxybutane with 1N aqueous sulfuric acid at 25° C to obtain 4-phthalimidobutanal. Subject the compound to reductive amination using ammonium chloride and sodium cyanoborohydride in aqueous methanol at 25° C to obtain 4-phthalimidobutylamine.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US04009328 |
| Quelldatensatz | uspto-grants-1977_02 |
| ORD ID | ord-3a306dee696a447e8932b041cbcf69d2 |
| Quellennotiz | uspto-grants-1977_02 |