1,3-Dibromo-2-propanone → 7-chloro-2-[[2-bromo-1-(bromomethyl)ethylidene]hydrazino]-5-(o-fluorophenyl)-3H-1,4-benzodiazepine

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	1,3-Dibromo-2-propanone	HCID 69952	—
Edukt	7-chloro-2-hydrazino-5-(o-fluorophenyl)-3H-1,4-benzodiazepine	HCID 12390887	—
Lösungsmittel	Tetrahydrofuran	HCID 8028	—
Produkt	7-chloro-2-[[2-bromo-1-(bromomethyl)ethylidene]hydrazino]-5-(o-fluorophenyl)-3H-1,4-benzodiazepine	HCID 21431394	—

Reaktionsschritte

In the manner given in Example 1, 7-chloro-2-hydrazino-5-(o-fluorophenyl)-3H-1,4-benzodiazepine in tetrahydrofuran can be treated with 1,3-dibromopropanone under nitrogen to give 7-chloro-2-[[2-bromo-1-(bromomethyl)ethylidene]hydrazino]-5-(o-fluorophenyl)-3H-1,4-benzodiazepine.

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US04028356
Quelldatensatz	uspto-grants-1977_06
ORD ID	ord-463a7a8ab7a2457c9ee7e5fcdcdbd439
Quellennotiz	uspto-grants-1977_06