Benzene, 1-isocyanato-4-nitro- → 6-Methyl-2[3-(p-nitrophenyl)ureido]-4-thiocyanatobenzothiazole

HRID 436815

Reaktionsgleichung

Reaktionsgleichung von HRID 436815
[NH2:1][C:2]1[S:3][C:4]2[CH:10]=[C:9]([CH3:11])[CH:8]=[C:7]([S:12][C:13]#[N:14])[C:5]=2[N:6]=1.[N+:15]([C:18]1[CH:23]=[CH:22][C:21]([N:24]=[C:25]=[O:26])=[CH:20][CH:19]=1)([O-:17])=[O:16]>CN(C)C=O>[CH3:11][C:9]1[CH:8]=[C:7]([S:12][C:13]#[N:14])[C:5]2[N:6]=[C:2]([NH:1][C:25]([NH:24][C:21]3[CH:20]=[CH:19][C:18]([N+:15]([O-:17])=[O:16])=[CH:23][CH:22]=3)=[O:26])[S:3][C:4]=2[CH:10]=1

Komponenten

4

Edukt 2

HCID 66012Benzene, 1-isocyanato-4-nitro-HCID 124057302-Amino-6-methyl-4-thiocyanatobenzothiazole

Produkt 1

HCID 124057346-Methyl-2[3-(p-nitrophenyl)ureido]-4-thiocyanatobenzothiazole

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

A mixture of 2-amino-6-methyl-4-thiocyanatobenzothiazole (35 g., 0.16 mole) in dimethylformamide (250ml.) was treated slowly with p-nitrophenyl isocyanate (27 g., 0.16 mole). The reaction was then heated under stirring on the steam bath for 5 hours. The mixture was then filtered hot. The solution was chilled in an ice bath and filtered. The product was combined with the solid initially filtered to give 40 g. (65%) of off-white solid.

Aufarbeitung

  1. temperatureThe reaction was then heated
  2. filtrationThe mixture was then filtered hot
  3. temperatureThe solution was chilled in an ice bath
  4. filtrationfiltered
  5. filtrationinitially filtered
  6. customto give 40 g

Quellen und Nachweise

ORD-Eintrag
ord-dad3e3216145481aac5d60dfbaffdb3f
Quelldatensatz
uspto-grants-1977_06
Patentnummer
US04028374

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