Ammonia → 3-Thiophenecarboxylic acid, 4-(aminosulfonyl)-, methyl ester

HRID 436828Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 436828
Cl[S:2]([C:5]1[C:6]([C:10]([O:12][CH3:13])=[O:11])=[CH:7][S:8][CH:9]=1)(=[O:4])=[O:3].[NH3:14]>C(Cl)(Cl)Cl>[S:2]([C:5]1[C:6]([C:10]([O:12][CH3:13])=[O:11])=[CH:7][S:8][CH:9]=1)(=[O:4])(=[O:3])[NH2:14]

Komponenten

4

Edukt 2

HCID 222AmmoniaHCID 12593671Methyl 4-(chlorosulfonyl)thiophene-3-carboxylate

Produkt 1

HCID 30422843-Thiophenecarboxylic acid, 4-(aminosulfonyl)-, methyl ester

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6212ChloroformLösungsmittel

Versuchsvorschrift

39.9 g (0.166 mole) of methyl 4-chlorosulfonylthiophene-3-carboxylate (VIII) is dissolved in 400 ml of absolute chloroform; ammonia is passed in at room temperature until the mixture has an alkaline reaction. After the mixture has been stirred for a further 3 hours (care being taken that the solution remains alkaline) it is extracted with water and the organic phase is dried and evaporated. The crystalline residue can be recrystallized from ethanol; however, for further use, digestion with ether is sufficient.

Aufarbeitung

  1. customis passed in at room temperature until the mixture
  2. customan alkaline reaction
  3. extractionis extracted with water
  4. customthe organic phase is dried
  5. customevaporated
  6. customThe crystalline residue can be recrystallized from ethanol

Quellen und Nachweise

ORD-Eintrag
ord-ea5cf465562c4a609d34e2c35fc2658b
Quelldatensatz
uspto-grants-1977_06
Patentnummer
US04028373

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