Ammonia → Methyl 3-(aminosulfonyl)-2-thiophenecarboxylate

HRID 436831

Reaktionsgleichung

Reaktionsgleichung von HRID 436831
Cl[S:2]([C:5]1[CH:9]=[CH:8][S:7][C:6]=1[C:10]([O:12][CH3:13])=[O:11])(=[O:4])=[O:3].[NH3:14]>C(Cl)(Cl)Cl>[S:2]([C:5]1[CH:9]=[CH:8][S:7][C:6]=1[C:10]([O:12][CH3:13])=[O:11])(=[O:4])(=[O:3])[NH2:14]

Komponenten

4

Edukt 2

HCID 222AmmoniaHCID 27367332-Thiophenecarboxylic acid, 3-(chlorosulfonyl)-, methyl ester

Produkt 1

HCID 101012Methyl 3-(aminosulfonyl)-2-thiophenecarboxylate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6212ChloroformLösungsmittel

Versuchsvorschrift

43.5 g (0.181 mole) of methyl 3-chlorosulfonylthiophene-2-carboxylate (VIII) is dissolved in 450 ml of absolute chloroform; ammonia is passed in at room temperature until the mixture has an alkaline reaction. After stirring the solution for a further 3 hours at room temperature (care being taken to keep the solution alkaline) it is extracted with water and the organic phase is dried and evaporated. The crystalline residue may be recrystallized from ethanol; however, for further reaction digestion with ether is sufficient.

Aufarbeitung

  1. customis passed in at room temperature until the mixture
  2. customan alkaline reaction
  3. extractionis extracted with water
  4. customthe organic phase is dried
  5. customevaporated
  6. customThe crystalline residue may be recrystallized from ethanol

Quellen und Nachweise

ORD-Eintrag
ord-51332c6b1b534fad9c929433efb4889c
Quelldatensatz
uspto-grants-1977_06
Patentnummer
US04028373

Verknüpfte Notizen

Wird geladen…