2-Thiazolidinone,4-thioxo- → HCID 178508330, Verbindung

HRID 436858

Reaktionsgleichung

Reaktionsgleichung von HRID 436858
[O:1]=[C:2]1[NH:6][C:5](=[S:7])[CH2:4][S:3]1.[NH:8]=[C:9]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[C:11](=N)[NH:10]1>CO>[NH:8]=[C:9]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[C:11](=[C:4]2[S:3][C:2](=[O:1])[NH:6][C:5]2=[S:7])[NH:10]1

Komponenten

4

Edukt 2

HCID 15395952-Thiazolidinone,4-thioxo-HCID 178508669HCID 178508669, Verbindung

Produkt 1

HCID 178508330HCID 178508330, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

To a stirred solution of 49.7 parts of 2-oxo-4-thioxothiazolidine in 990 parts of methanol there was added at 40° C. and under an atmosphere of nitrogen 54.3 parts of powdered 1,3-diiminoisoindoline. Initially, a thick slurry resulted. The reaction mixture was stirred at room temperature for two hours during which time the mixture gradually thinned. The mixture was then heated at reflux for approximately two hours and after cooling to 25° C., was filtered. The collected solid was washed with fresh methanol and dried in vacuo at 50° C. to obtain 1-imino-3-(2-oxo-4-thioxo-5-thiazolidinylidene)isoindoline as an orange powder melting at 267°-8° C. (dec.).

Aufarbeitung

  1. customInitially, a thick slurry resulted
  2. temperatureThe mixture was then heated
  3. temperatureat reflux for approximately two hours
  4. temperatureafter cooling to 25° C.
  5. filtrationwas filtered
  6. washThe collected solid was washed with fresh methanol
  7. customdried in vacuo at 50° C.

Quellen und Nachweise

ORD-Eintrag
ord-22216317c05d493e81fdc0e0761e14fe
Quelldatensatz
uspto-grants-1977_06
Patentnummer
US04028372

Verknüpfte Notizen

Wird geladen…