Dimethylamine → 3-Dimethylamino-1,1-diphenyl-propan-2-ol

HRID 436945

Reaktionsgleichung

Reaktionsgleichung von HRID 436945
[C:1]1([CH:7]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH:8]([OH:11])[CH2:9]Br)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:18][NH:19][CH3:20]>C(O)C>[CH3:18][N:19]([CH3:20])[CH2:9][CH:8]([OH:11])[CH:7]([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)[C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Komponenten

4

Edukt 2

HCID 674DimethylamineHCID 125490671,1-Diphenyl-3-bromopropan-2-ol

Produkt 1

HCID 125491223-Dimethylamino-1,1-diphenyl-propan-2-olAusbeute 75 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

1,1-Diphenyl-3-bromopropan-2-ol (500 mg.) prepared as described in Example 20 was treated with excess dimethylamine in ethanol and the solution allowed to stand overnight. Solvent was removed by evaporation and the residue dissolved in dilute hydrochloric acid and ether. Basification of the acid extract and isolation through ether in the usual manner gave 3-dimethylamino-1,1-diphenyl-propan-2-ol (330 mg., 75%), m.p. 72° - 73°.

Aufarbeitung

  1. customSolvent was removed by evaporation
  2. dissolutionthe residue dissolved in dilute hydrochloric acid
  3. extractionBasification of the acid extract

Quellen und Nachweise

ORD-Eintrag
ord-1dfed4f348254ebc9e20da6f22ffbfc0
Quelldatensatz
uspto-grants-1977_06
Patentnummer
US04028415

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