Potassium Carbonate → 2-(Tert-butoxy)acetic acid

HRID 4371

Reaktionsgleichung

Reaktionsgleichung von HRID 4371
C(=O)([O-])[O-].[K+].[K+].[C:7]([O:11][CH2:12][C:13]([O:15]CCCC)=[O:14])([CH3:10])([CH3:9])[CH3:8]>CO.O>[C:7]([O:11][CH2:12][C:13]([OH:15])=[O:14])([CH3:10])([CH3:9])[CH3:8]

Komponenten

4

Edukt 2

HCID 11430Potassium CarbonateHCID 14050415Butyl tert-butoxyacetate

Produkt 1

HCID 27609982-(Tert-butoxy)acetic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 22242641Methanol--water (1/1)Lösungsmittel

Reaktionsbedingungen

Temperatur
0 °C

Versuchsvorschrift

To 100 ml of a 50:50 (v/v) methanol/water solution containing 14.35 g of potassium carbonate, was added n-butyl 2-tert-butoxyacetate (6.50 g, 0.0346 mol). The mixture was heated at reflux for 17 hours and the volatiles removed on a flash evaporator. The remaining solution was cooled to approximately 0° C. and acidified to pH 3-4 with cold 50% aqueous hydrogen chloride. The product was extracted with ether, the ether extract washed with brine and dried over magnesium sulfate, then concentrated in vacuo to give the title compound as a yellow liquid.

Aufarbeitung

  1. temperatureThe mixture was heated
  2. temperatureat reflux for 17 hours
  3. customthe volatiles removed on a flash evaporator
  4. extractionThe product was extracted with ether
  5. extractionthe ether extract
  6. washwashed with brine
  7. dry with materialdried over magnesium sulfate
  8. concentrationconcentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-683c16909174462faf1b49adbea715f3
Quelldatensatz
uspto-grants-1988_02
Patentnummer
US04725620

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