Sodium Carbonate → cis(+/-)-4-Chloro-N-[3-ethoxy-1-(1,3-thiazol-2-yl)piperidin-4-yl]-5-ethyl-1H-imidazole-2-carboxamide

Beteiligte Stoffe

Reaktionsschritte

cis(±)-4-Chloro-N-(3-ethoxypiperidin-4-yl)-5-ethyl-1H-imidazole-2-carboxamide hydrochloride obtained in Example (131a) (100 mg, 0.297 mmol), 2-bromothiazole (0.040 mL, 0.44 mmol) and sodium carbonate (157 mg, 1.48 mmol) were suspended in DMF (3 mL). The suspension was subjected to the same operation as in Example (131b) to obtain 45.8 mg of the title compound as a colorless oily substance (40%).

Herkunft & Nachweise