Potassium Carbonate → HCID 21430607, Verbindung

HRID 437221Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 437221
Br[CH2:2][CH2:3][C:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[CH2:6][CH:5]=1.[C:13]([NH:21][CH:22]1[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]1)(=[O:20])[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1.C(=O)([O-])[O-].[K+].[K+]>C(O)(C)C>[CH2:6]1[C:7]2[C:12](=[CH:11][CH:10]=[CH:9][CH:8]=2)[C:4]([CH2:3][CH2:2][N:25]2[CH2:26][CH2:27][CH:22]([NH:21][C:13](=[O:20])[C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[CH2:23][CH2:24]2)=[CH:5]1

Komponenten

5

Edukt 3

HCID 11430Potassium CarbonateHCID 118120N-4-PiperidylbenzamideHCID 121780961-bromo-2-(3-indenyl)ethane

Produkt 1

HCID 21430607HCID 21430607, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3776IsopropanolLösungsmittel

Versuchsvorschrift

3-(2-Bromoethyl)indene (1.12 g.), 4-benzamidopiperidine (1.02 g.) and potassium carbonate (1.38 g.) were heated under reflux in isopropanol (25 ml.) for 24 hours. The mixture was filtered and the filtrate was evaporated. Trituration of the residue with ether gave a solid which was recrystallised twice from aqueous ethanol to provide the title compound, m.p. 148°-149° C. (Found: C, 79.7; H, 7.6; N, 8.0. C23H26N2O requires C, 79.7; H, 7.6; N, 8.1%).

Aufarbeitung

  1. filtrationThe mixture was filtered
  2. customthe filtrate was evaporated
  3. customTrituration of the residue with ether gave a solid which
  4. customwas recrystallised twice from aqueous ethanol

Quellen und Nachweise

ORD-Eintrag
ord-47494834c1144272b3ab85191e977b1c
Quelldatensatz
uspto-grants-1977_06
Patentnummer
US04029801

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