Dicyclohexylcarbodiimide → Nalpha-t-Butoxycarbonyl-D-alanyl-D-leucine

HRID 437331

Reaktionsgleichung

Reaktionsgleichung von HRID 437331
C(OC([NH:8][C@@H:9]([C:14]([OH:16])=[O:15])[CH2:10][CH:11]([CH3:13])[CH3:12])=O)(C)(C)C.[C:17]([O:21][C:22]([NH:24][C@@H:25]([C:27]([OH:29])=O)[CH3:26])=[O:23])([CH3:20])([CH3:19])[CH3:18].C1(N=C=NC2CCCCC2)CCCCC1>C(Cl)(Cl)Cl>[C:17]([O:21][C:22]([NH:24][C@@H:25]([C:27]([NH:8][C@@H:9]([C:14]([OH:16])=[O:15])[CH2:10][CH:11]([CH3:13])[CH3:12])=[O:29])[CH3:26])=[O:23])([CH3:18])([CH3:19])[CH3:20]

Komponenten

5

Edukt 3

HCID 10868DicyclohexylcarbodiimideHCID 637604tert-Butoxycarbonyl-D-leucineHCID 637606BOC-D-alanine

Produkt 1

HCID 53724831Nalpha-t-Butoxycarbonyl-D-alanyl-D-leucine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6212ChloroformLösungsmittel

Versuchsvorschrift

Nα-t-Butoxycarbonyl-D-leucine resin (53 g., 42.9 mmol) is deprotected as in part (b), and Nα-t-butoxycarbonyl-D-alanine (8.5 g., 45 mmol) is added followed by the addition of dicyclohexylcarbodiimide, 9.3 g., 45 mmol in chloroform, after 15 to 30 minutes, followed by agitation for 18 hours. The product is separated by filtration and washed three times with dichloromethane, 250 ml., and dried.

Aufarbeitung

  1. additionis added
  2. customThe product is separated by filtration
  3. washwashed three times with dichloromethane, 250 ml
  4. custom, and dried

Quellen und Nachweise

ORD-Eintrag
ord-a9f21c9effb14dcaa24c62b65729a608
Quelldatensatz
uspto-grants-1977_06
Patentnummer
US04031071

Verknüpfte Notizen

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