3-Bromo-1-propanol → HCID 13239624, Verbindung

HRID 437386

Reaktionsgleichung

Reaktionsgleichung von HRID 437386
[CH3:1][C@H:2]1[CH2:7][CH2:6][CH2:5][C@@H:4]([CH3:8])[NH:3]1.Br[CH2:10][CH2:11][CH2:12][OH:13]>C1(C)C(C)=CC=CC=1>[CH3:1][C@H:2]1[CH2:7][CH2:6][CH2:5][C@@H:4]([CH3:8])[N:3]1[CH2:10][CH2:11][CH2:12][OH:13]

Komponenten

4

Edukt 2

HCID 123083-Bromo-1-propanolHCID 641768rel-(2R,6S)-2,6-Dimethylpiperidine

Produkt 1

HCID 13239624HCID 13239624, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 7237O-XyleneLösungsmittel

Versuchsvorschrift

A stirred solution of 460 g. of cis-2,6-dimethylpiperidine in 300 ml. of xylene is treated with 278 g. of 3-bromopropanol over a period of 15 minutes. The mixture is stirred and heated at reflux for 2 hours, then allowed to cool while stirring for 16 hours. The mixture is filtered and the filtrate evaporated at reduced pressure. The residue is distilled at reduced pressure to give cis-2,6-dimethyl-1-piperidinepropanol; b.p. 147°-149° C./25 mm.

Aufarbeitung

  1. temperatureheated
  2. temperatureat reflux for 2 hours
  3. temperatureto cool
  4. stirringwhile stirring for 16 hours
  5. filtrationThe mixture is filtered
  6. customthe filtrate evaporated at reduced pressure
  7. distillationThe residue is distilled at reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-c4a51d1f1ffb49698711afb4b5e819b1
Quelldatensatz
uspto-grants-1977_06
Patentnummer
US04031101

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