Thionyl Chloride → 5,6-Dichloro-2-(trifluoromethyl)-1H-imidazo[4,5-b]pyridine
Reaktionsgleichung
O[N:2]1[C:10]2[C:5](=[N:6][C:7]([Cl:11])=[CH:8][CH:9]=2)[N:4]=[C:3]1[C:12]([F:15])([F:14])[F:13].S(Cl)([Cl:18])=O>>[Cl:11][C:7]1[N:6]=[C:5]2[N:4]=[C:3]([C:12]([F:15])([F:14])[F:13])[NH:2][C:10]2=[CH:9][C:8]=1[Cl:18]Komponenten
3
Versuchsvorschrift
1-Hydroxy-5-chloro-2-(trifluoromethyl)-1H-imidazo [4,5-b] pyridine (100 milligrams) was mixed with 10milliliters of thionyl chloride and the mixture refluxed on a steam bath for ten hours. The thionyl chloride was then evaporated and the residue, the desired 5,6-dichloro-2-(trifluoromethyl) -1H-imidazo [4,5-b] pyridine product, was shaken with water and separated by filtration, m.p. 222° -24° C.
Aufarbeitung
- temperaturethe mixture refluxed on a steam bath for ten hours
- customThe thionyl chloride was then evaporated
- customseparated by filtration, m.p. 222° -24° C.
Quellen und Nachweise
- ORD-Eintrag
- ord-7f16efa904814483ada2cdd69bf44621
- Quelldatensatz
- uspto-grants-1977_06
- Patentnummer
- US04031107
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