Nitric Acid → HCID 12535827, Verbindung

HRID 437439Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 437439
[O:1]=[C:2]1[NH:7][C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=2[O:14][CH2:15][CH3:16])=[N:5][CH:4]=[C:3]1[C:17]([O:19][CH2:20][CH3:21])=[O:18].[N+:22]([O-])([OH:24])=[O:23].S(=O)(=O)(O)O>>[O:1]=[C:2]1[NH:7][C:6]([C:8]2[CH:13]=[C:12]([N+:22]([O-:24])=[O:23])[CH:11]=[CH:10][C:9]=2[O:14][CH2:15][CH3:16])=[N:5][CH:4]=[C:3]1[C:17]([O:19][CH2:20][CH3:21])=[O:18]

Komponenten

4

Edukt 3

HCID 944Nitric AcidHCID 1118Sulfuric AcidHCID 12535800HCID 12535800, Verbindung

Produkt 1

HCID 12535827HCID 12535827, VerbindungAusbeute 55 %

Versuchsvorschrift

Ethyl 1,6-dihydro-6-oxo-2-(2-ethoxyphenyl)pyrimidine-5-carboxylate (1.0 g., 3.46 mmoles) was added over a twenty minute period to a cooled (ice-water), stirred mixture of 70% nitric acid (1.7 ml., d=1.42) and 96% sulfuric acid (0.29 ml., d=1.84). The mixture was stirred at room temperature for 19 hours. The solution was poured into ice-water (300 ml.). The mixture was triturated and then filtered. The collected solid was recrystallized from acetonitrile to give the title compound (0.64 g., 55%), m.p. 222°-224°.

Aufarbeitung

  1. stirringThe mixture was stirred at room temperature for 19 hours
  2. customThe mixture was triturated
  3. filtrationfiltered
  4. customThe collected solid was recrystallized from acetonitrile

Quellen und Nachweise

ORD-Eintrag
ord-4c6c7cfee9414785ba505ed1cfda5a9c
Quelldatensatz
uspto-grants-1977_06
Patentnummer
US04031093

Notizen zur Reaktion

Wird geladen…