Hydrochloric Acid → HCID 12535843, Verbindung

HRID 437443Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 437443
[O:1]=[C:2]1[NH:7][C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=2[O:14][CH2:15][CH3:16])=[N:5][CH:4]=[C:3]1[C:17]([O:19]CC)=[O:18].[OH-].[Na+].Cl>>[O:1]=[C:2]1[NH:7][C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=2[O:14][CH2:15][CH3:16])=[N:5][CH:4]=[C:3]1[C:17]([OH:19])=[O:18]

Komponenten

4

Edukt 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 12535800HCID 12535800, Verbindung

Produkt 1

HCID 12535843HCID 12535843, VerbindungAusbeute 100,2 %

Versuchsvorschrift

A solution of ethyl 1,6-dihydro-6-oxo-2-(2-ethoxyphenyl)pyrimidine-5-carboxylate (2 g., 6.9 mmole) in 1N NaOH (20 ml., 20 mmole) was heated at reflux for 10 minutes. The solution was cooled and acidified with 6N HCl to yield the title product (1.8 g., m.p. 168°-184°). Recrystallization from acetonitrile gave 1.2 g. of colorless crystals, m.p. 186°-188°.

Aufarbeitung

  1. temperatureat reflux for 10 minutes
  2. temperatureThe solution was cooled

Quellen und Nachweise

ORD-Eintrag
ord-ce4c3b87b1b94626854d964a88691da3
Quelldatensatz
uspto-grants-1977_06
Patentnummer
US04031093

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