Pinacolone → Methyl pivaloylacetate

HRID 437480

Reaktionsgleichung

Reaktionsgleichung von HRID 437480
[H-].[Na+].[CH3:3][C:4](=[O:9])[C:5]([CH3:8])([CH3:7])[CH3:6].[C:10](=O)([O:13]C)[O:11][CH3:12]>CN(C)P(=O)(N(C)C)N(C)C>[CH3:12][O:11][C:10](=[O:13])[CH2:3][C:4](=[O:9])[C:5]([CH3:8])([CH3:7])[CH3:6]

Komponenten

5

Edukt 3

HCID 6416PinacoloneHCID 12021Dimethyl CarbonateHCID 24758Sodium hydride

Produkt 1

HCID 99597Methyl pivaloylacetateAusbeute 83,5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 12679HexamethylphosphoramideLösungsmittel

Versuchsvorschrift

60 g of sodium hydride were suspended in 450 cc of dimethyl carbonate and 100 cc of hexamethyl phosphoric acid triamide. 100 g of pinacolone (92%) were added slowly at 45° C and on completion of the addition, the reaction mixture was processed as described in 3 above. The yield was 83.5% of pivaloyl acetic acid methyl ester.

Quellen und Nachweise

ORD-Eintrag
ord-0fb85a1d813f4f5ea5765711fed7dda6
Quelldatensatz
uspto-grants-1977_06
Patentnummer
US04031130

Verknüpfte Notizen

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