Butyl Isothiocyanate → 3-Butyl-1-[4-(2-formylhydrazino)phenyl]thiourea

HRID 437508

Reaktionsgleichung

Reaktionsgleichung von HRID 437508
[CH:1]([NH:3][NH:4][C:5]1[CH:10]=[CH:9][C:8]([NH2:11])=[CH:7][CH:6]=1)=[O:2].[CH2:12]([N:16]=[C:17]=[S:18])[CH2:13][CH2:14][CH3:15]>C(O)C>[CH2:12]([NH:16][C:17](=[S:18])[NH:11][C:8]1[CH:9]=[CH:10][C:5]([NH:4][NH:3][CH:1]=[O:2])=[CH:6][CH:7]=1)[CH2:13][CH2:14][CH3:15]

Komponenten

4

Edukt 2

HCID 11613Butyl IsothiocyanateHCID 113189Hydrazinecarboxaldehyde, 2-(4-aminophenyl)-

Produkt 1

HCID 214278143-Butyl-1-[4-(2-formylhydrazino)phenyl]thiourea

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

1-Formyl-2-(4-aminophenyl)hydrazine (7.5 g, 0.05 mole) and butyl isothiocyanate (5.7 g, 0.05 mole) were mixed in ethanol (120 ml) and the mixture was refluxed for 30 minutes. The resulting solution was chilled in ice and upon scratching the product crystallized out as a white solid. The mixture was filtered and the solid was washed with ether. The product was dried to give a pale tan crystalline powder. Yield 9.8 g (74%), m.p. 129°-131° C.

Aufarbeitung

  1. temperaturethe mixture was refluxed for 30 minutes
  2. temperatureThe resulting solution was chilled in ice
  3. customcrystallized out as a white solid
  4. filtrationThe mixture was filtered
  5. washthe solid was washed with ether
  6. customThe product was dried
  7. customto give a pale tan crystalline powder

Quellen und Nachweise

ORD-Eintrag
ord-634785fa5bdd4c95b79e83f97e19bd12
Quelldatensatz
uspto-grants-1977_06
Patentnummer
US04031127

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