Epichlorohydrin → HCID 21428798, Verbindung
Reaktionsgleichung
[OH:1][C:2]1[C:8]2[S:9][CH:10]=[CH:11][C:7]=2[C:6](=[O:12])[C:5]2[CH:13]=[CH:14][CH:15]=[CH:16][C:4]=2[CH:3]=1.N1CCCCC1.[CH2:23]([CH:25]1[O:27][CH2:26]1)[Cl:24]>>[Cl:24][CH2:23][CH:25]([OH:27])[CH2:26][O:1][C:2]1[C:8]2[S:9][CH:10]=[CH:11][C:7]=2[C:6](=[O:12])[C:5]2[CH:13]=[CH:14][CH:15]=[CH:16][C:4]=2[CH:3]=1Komponenten
4
Versuchsvorschrift
A mixture of 15.0 g of 10-hydroxy-4H-benzo[4,5]cyclohepta[1,2-b]thiophen-4-one, 150 ml of epichlorohydrin and 0.7 ml of piperidine is heated to the boil for 30 minutes. After concentration by evaporation at reduced pressure, the mixture is dried at 40°, whereupon a mixture of 10-(2,3-epoxypropoxy)-4H-benzo[4,5]-cyclohepta[1,2-b]thiophen-4-one and 10-(3-chloro-2-hydroxypropoxy)-4H-benzo[4,5]cyclohepta[1,2-b]thiophen-4-one is obtained, which is used further as such.
Aufarbeitung
- temperature